Power of variance component linkage analysis to detect epistasis
Mitchell BD, Ghosh S, Schneider JL, Birznieks G, Blangero J
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio,
Texas 78245-0549, USA.
Genetic Epidemiology, 14(6):1017-1022 (1997)
Abstract
Variance component methods are now being used in linkage analysis to detect genes
influencing complex diseases. These methods are easily extended to allow for
simultaneous estimation of both the additive effects of multiple loci on phenotypic
variation (conditional oligogenic analysis) and the additive interaction (epistatic) effects
among loci. We performed linkage analyses on 200 of the simulated replicates in order
to evaluate the power to detect the main effects of MG1 and MG2 on Q1 as well as their
interaction effects. The power to detect the main effect of MG1 was moderately good,
although the power to detect MG2 and the MG1 x MG2 interaction was poor.
Variance component linkage analysis