Assessing Linkage on Chromosome 5 Using Components
of Variance Approach: Univariate Versus Multivariate
de Andrade M; Thiel TJ; Yu L; Amos CI
Department of Epidemiology, University of Texas M.D. Anderson Cancer
Center, Houston 77030-4095, USA.
Genetic Epidemiology, 14(6):773-778 (1997)
Abstract
We report results when one disease related quantitative trait (Q1) is analyzed
versus multiple related quantitative traits using a components of variance
approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used
age, sex and environmental factor (EF) as covariates. Analysis with
ascertainment correction of samples selected through probands with extremely
high trait values was also performed and is presented. Testing procedures to
detect linkage using the components of variance approach are discussed. The
univariate and multivariate analyses showed effects of locus 15 on chromosome
5 only for Q1. This result was confirmed when using ascertainment correction.
Variance component linkage analysis