Allele-Sharing Models: LOD Scores and Accurate Linkage Tests
Augustine Kong, Nancy J. Cox
American Journal of Human Genetics, 61, 1179-1188 (Nov 1997)
Abstract
Starting with a test statistic for linkage analysis
based on allele sharing, we propose an associated one-parameter
model. Under general missing-data patterns, this model
allows exact calculation of likelihood ratios and
LOD scores and has been implemented by a simple
modification of existing software. Most important,
accurate linkage tests can be performed. Using an
example, we show that some previously suggested approaches
to handling less than perfectly informative data can
be unacceptably conservative. Situations in which this
model may not perform well are discussed, and an
alternative model that requires additional computations
is suggested.
Allele-sharing linkage analysis