A Chromosome-based Method to Infer IBD Scores for
Missing and Ambiguous Markers
C. Gu, B.K. Suarez, T. Reich, A.A. Todorov
Genetic Epidemiology, 12(6), 871-876 (1995)
Abstract
We propose a probability model to impute missing identical-by-descent (IBD)
vectors for linkage analysis, when adjacent marker loci are typed and interference is
estimable. A chromosome-based IBD distribution, conditioned on available marker data, is
computed using a fast algorithm to estimate the joint probability of genes IBD at several
equally spaced linked loci. Weighted IBD vectors are then used in various test statistics for
linkage analysis. As an example, we analyzed the 18 affected sib pairs in the GAW9
Problem 1 data set using Risch's lod-score test.
Allele-sharing linkage analysis