Multipoint linkage analysis using sib pairs: an interval mapping
approach for dichotomous outcomes
J.M. Olson
American Journal of Human Genetics, 56(3),788-798
(Mar 1995)
Abstract
I propose an interval mapping approach suitable for a dichotomous
outcome, with emphasis on samples of affected sib pairs. The method
computes a lod score for each of a set of locations in the interval
between two flanking markers and takes as its estimate of
trait-locus location the maximum lod score in the interval, provided
it exceeds the prespecified critical value. Use of the method
depends on prior knowledge of the genetic model for the disease only
through available estimates of recurrence risk to relatives of
affected individuals. The method gives an unbiased estimate of
location, provided the recurrence risk are correctly specified and
provided the marker identity-by-descent probabilities are jointly,
rather than individually, estimated. I also discuss use of the
method for traits determined by two loci and give an approximation
that has good power for a wide range of two-locus models.
Allele-sharing linkage analysis