Multipoint interval mapping of quantitative trait loci, using sib pairs
D.W. Fulker, S.S. Cherny, L.R. Cardon
American Journal of Human Genetics, 56(5), 1224-1233 (May,1995)
Abstract
The sib-pair interval-mapping procedure of Fulker and Cardon is
extended to take account of all available marker information on a
chromosome simultaneously. The method provides a computationally
fast multipoint analysis of sib-pair data, using a modified
Haseman-Elston approach. It gives results very similar to those of
the earlier interval-mapping procedure when marker information is
relatively uniform and a coarse map is used. However, there is a
substantial improvement over the original method when markers differ
in information content and/or when a dense map is employed. The
method is illustrated by using simulated sib-pair data.
Allele-sharing linkage analysis