Genetic dissection of complex traits
[Review]
E.S. Lander, N.J. Schork
Science, 265(5181),2037-2048
(Sept 30, 1994)
[erratum appears in 266(5184),353 (Oct 21, 1994)].
Abstract
Medical genetics was revolutionized during the 1980s by the
application of genetic mapping to locate the genes responsible for
simple Mendelian diseases. Most diseases and traits, however, do not
follow simple inheritance patterns. Genetics have thus begun taking
up the even greater challenge of the genetic dissection of complex
traits. Four major approaches have been developed: linkage analysis,
allele-sharing methods, association studies, and polygenic analysis
of experimental crosses. This article synthesizes the current state
of the genetic dissection of complex traits--describing the methods,
limitations, and recent applications to biological problems.
[References: 149]
Allele-sharing linkage analysis