Linkage analysis in nuclear families
1: Optimality criteria for affected sib-pair tests.
M. Knapp, S.A. Seuchter, M.P. Baur
Human Heredity, 44(1),37-43 (Jan-Feb 1994)
Abstract
The affected sib-pair method can be applied to investigate linkage
between a marker locus and a disease. Several statistics have been
proposed to test if the observed pattern of marker alleles shared
identically by descent (ibd) is compatible with the null hypothesis
of no linkage. Here, we consider different optimality criteria for
sib-pair linkage tests. While for recessive inherited diseases the
mean test is found to be uniformly (in theta) most powerful, it can
also be shown that, irrespective of the mode of inheritance, the
mean test is the locally optimal test.
Allele-sharing linkage analysis