A sib-pair approach to interval mapping of quantitative trait loci
D.W. Fulker, L.R. Cardon
American Journal of Human Genetics, 54(6),1092-1103 (Jun 1994)
[erratum appears in 55(2),419 (Aug 1994)].
Abstract
An interval mapping procedure based on the sib-pair method of
Haseman and Elston is developed, and simulation studies are carried
out to explore its properties. The procedure is analogous to other
interval mapping procedures used with experimental material, such as
plants and animals, and yields very similar results in terms of the
location and effect size of a quantitative trait locus (QTL). The
procedure offers an advantage over the conventional Haseman and
Elston approach, in terms of power, and provides useful information
concerning the location of a QTL. Because of its simplicity, the
method readily lends itself to the analysis of selected samples for
increased power and the evaluation of multilocus models of complex
phenotypes.
Allele-sharing linkage analysis