The power of interval mapping of quantitative trait loci, using
selected sib pairs
L.R. Cardon and D.W. Fulker
American Journal of Human Genetics, 55(4), 825-833
(Oct, 1994)
Abstract
The interval-mapping procedure of Fulker and Cardon for analysis of
a quantitative-trait loci (QTL) is extended for application to
selected samples of sib pairs. Phenotypic selection of sib pairs,
which is known to yield striking increases in power when a single
marker is used, provides further increases in power when the
interval-mapping approach is used. The greatest benefits of the
combined approach are apparent with coarse maps, where QTLs of
relatively modest (15%-20%) heritability can be detected with widely
spaced markers (40-60 cM apart) in reasonably sized sibling samples.
Useful information concerning QTL location is afforded by interval
mapping in both selected and unselected samples.
Allele-sharing linkage analysis