Power of affected sibling method tests for linkage
C. Tierney, B. McKnight
Human Heredity, 43(5),276-287
(Sept-Oct 1993)
Abstract
When the mode of inheritance of a disease susceptibility (DS) gene
is unknown, the affected sibling method can be applied to study
whether a DS gene and a marker gene are linked. This method
considers how k affected siblings (k > or = 2) share marker alleles
identically by descent from their parents. Several nonparametric and
likelihood ratio test statistics have been proposed for the use with
affected sibling marker gene data. We compare the power of these
proposed tests for linkage under different genetic models via
simulation. We find that, in general, the likelihood ratio tests are
slightly more powerful, but the gain in power may not warrant the
additional computation burden imposed.
Allele-sharing linkage analysis