Improved sib-pair linkage test for disease susceptibility loci
J.J. Faraway
Genetic Epidemiology,10(4),225-233 (1993)
[erratum appears in 11(1), 99 (1994)]
Abstract
An improved sib-pair test for linkage is introduced which is
superior to the previously proposed tests. The test is derived from
the standard chi-squared goodness of fit statistic by restricting
the alternative hypothesis to the genetically possible. Critical
values are given and exact power comparisons are made with the
previously proposed tests. The new test is shown to be more powerful
for finite samples as well as being asymptotically uniformly most
powerful.
Allele-sharing linkage analysis