Extensions to Methods of Sib-pair Linkage Analyses
M.D. Flanders, M.J. Khoury
Genetic Epidemiology, 8(6), 399-408 (1991)
Abstract
Sib-pair methods provide simple, robust, easily implemented ways to
screen for linkage between a marker locus and a suspected disease
susceptibility locus. The basic analysis reflects the idea that, in
the presence of linkage, siblings who share more alleles at the
marker locus should also tend to be concordant for disease.
Available sib-pair methods do not lead directly to estimates of risk
associated with nongenetic factors, may not account for a variable
age-at-onset, or may require that the age-at-onset distribution be
known. In this paper, we propose a method for sib-pair linkage
analyses that allows for a variable age-at-onset using a logistic
model, easily allows modelling of nongenetic factors, reflects the
correlation of sibs within a sibship, and allows for nonzero risk in
those without the susceptibility genotype. Based on a limited number
of simulations, the method has as good or better power than another
recently described method that also allows for a variable
age-at-onset.
Allele-sharing linkage analysis