Use of the Robust Sib-pair Method to Screen for Single Locus,
Multiple Locus, and Pleiotropic Effects:
Application to Traits Related to Hypertension.
A.F. Wilson, R.C. Elston, D.T. Lieu, R.M. Siervogel
American Journal of Human Genetics, 48, 862-872 (1991)
Abstract
Robust sib-pair linkage analysis can be used as a screening tool in
the search for the potential involvement of single-loci,
multiple-loci, and pleiotropic effects of single loci underlying
phenotypic variation. Four large families were each ascertained
through one adult white male with essential hypertension. The robust
sib-pair method was used to screen these families for evidence of
linkage between 39 quantitative traits related to hypertension and
25 genetic marker loci. All traits were analyzed on the
untransformed, square-root and log-transformed scales. Among other
findings, there is a suggestion of linkage between the
6-phosphogluconate dehydrogenase locus on chromosome 1p36 and mean
fifth-phase diastolic blood pressure. There may also be linkage
between the following markers and traits: the adenylate kinase-1
marker and/or the Lewis blood group marker and the traits height,
weight, and biacromial breadth; the glyoxylase I marker and the
traits upper-arm circumference and suprailiac skinfold thickness;
the ABO blood group and adenylate kinase-1 markers on chromosome
9q34 and the third component of complement marker on chromosome
19p13 and dopamine-beta-hydroxylase; and the P1 blood group and the
traits weight and 1-h postload serum glucose level.
Allele-sharing linkage analysis