The Probabilistic Determination of Identity-by-Descent
Sharing for Pairs of Relative From Pedigrees
C.I. Amos, D.V. Dawson, R.C. Elston
American Journal of Human Genetics, 47, 842-853 (1990)
Abstract
Methods for detecting genetic linkage are more powerful when they
fully use all of the data collected from pedigrees. We first discuss
a method for obtaining the probability that a pedigree member has a
given genotype, conditional on the phenotypes of his relatives. We
then develop a rapid method to obtain the conditional probabilities
of identity-by-descent sharing of marker alleles for all related
pairs of individuals from extended pedigrees. The method assumes
that the individuals are noninbred and that the relationship between
genotype and phenotype is known for the marker locus studied. The
probabilities of identity-by-descent sharing among relative pairs,
conditional on marker phenotype information, can then be used in any
of the model free tests for linkage between a trait locus and a
marker locus.
Allele-sharing linkage analysis