A Comparison of Three Affected-sib-pair Scoring Methods
to Detect HLA-linked Disease Susceptibility Genes
B.K. Suarez, P. Van Eerdewegh
American Journal of Medical Genetics, 18, 135-146 (1984)
Abstract
Two widely used affected-sib-pair scoring procedures (the Green and Woodrow
[1977] procedure, and the method of forming all possible affected-sib-pairs) are compared
with a new method for their relative efficiency in detecting the presence of an HLA-linked
disease susceptibility gene. Their relative performance is investigated by extensive computer
simulations over a large number of disease transmission models. On the average, the new
procedure appears to outperform the Green and Woodrow method and the
"all-possible-pairs" method.
Allele-sharing linkage analysis