Variability in Sib Pair Genetic Identity
B.K. Suarez, T. Reich, P.M. Fishman
Human Heredity, 29(1), 37-41 (1979).
Abstract
Using a realistic model of meiotic crossing over the variability in full sib genetic
identity is estimated by simulating 200 independent pairs of sibs. The standard deviation of
the percentage of the autosomal genome identical by descent (IBD) was found to be about
0.056. Simulations of sibships larger than size two revealed that the average within sibship
standard deviation is between 0.054 and 0.056, thus indicating that sib pair variability is
insensitive to the nonindependence structure present when considering all possible sib pairs
contained in a large sibship.
Allele-sharing linkage analysis