The Affected Sib Pair IBD Distribution for HLA-linked Disease
Susceptibility Genes
B.K. Suarez
Tissue Antigens , 12, 87-93 (1978)
Abstract
The distribution of identity by descent (IBD) scores for sib pairs affected with a
disease determined by a disease susceptibility (DS) locus tightly linked to the HLA complex
is derived. It is shown that the sib pair IBD distribution differs from its a priori distribution
and, moreover, is completely specified by three observable population parameters--the
additive and dominance variances and the prevalence of the disease in the population. An
application of the model is illustrated using data on juvenile diabetes mellitus.
Allele-sharing linkage analysis