A Robust Method for the Detection of Linkage in Familial Diseases
P.M. Fishman, B. Suarez, S.E. Hodge, T. Reich
American Journal of Human Genetics, 30, 308-321 (1978)
Abstract
A nonparametric method for the detection of critical genes associated with
familial disease was presented. The method involves the detection of deviations from
expected identity by descent distributions at polymorphic marker loci for affected sib pairs.
The method thus avoids the difficulties arising from incomplete penetrance, variable age of
onset and other complications present in other forms of linkage analysis. The theoretical
properties of method were worked out in detail for two important cases -- that of an
incompletely penetrant recessive or incompletely penetrant dominant critical autosomal
gene linked to a codominant marker locus. An easily implementable decision rule for the
detection of linkage was proposed, and its operating characteristics for a variety of alternative
hypothesis were obtained.
Allele-sharing linkage analysis