Construction of human linkage maps: likelihood calculations for
multilocus linkage analysis
Lathrop GM, Lalouel JM, White RL
Genetic Epidemiology 1986;3(1):39-52
Abstract
Methods are given for efficient calculation of the likelihood for
multilocus linkage in families comprised of grandparents, parents,
and children. Such families are being used in large-scale cooperative
efforts to build a detailed linkage map of the human genome. The
methods are illustrated by an application to loci on chromosome 13.
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